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Biomedical Accelerator Mass Spectrometry: Improving Human Health One Atom at a Time
Sat, February 10 @ 9:30 am
Presenters: Mike Malfatti with Katherine Huang, Dougherty Valley HS
Accelerator mass spectrometry (AMS) is a sensitive mass spectrometric method for detecting and quantifying rare long-lived isotopes with high precision. This technique is widely employed in the earth and environmental sciences and is now being applied in the biomedical fields. AMS is primarily used to in the areas of pharmacology and toxicology to investigate the absorption, distribution, metabolism, and excretion of radiolabeled drugs, chemicals, and nutrients, as well as in the detection of chemically modified DNA and proteins in animal models and humans. The exquisite sensitivity (10-18 mol) of AMS allows for the use of low chemical and radioisotope doses and relatively small sample sizes, which enables studies to be performed safely in humans, using exposures that are environmentally or therapeutically relevant. Such studies include risk assessment of environmental toxicants, drug candidate selection, absolute bioavailability determination, pharmacokinetic evaluation, and assessment of drug-target binding as a biomarker of response to chemotherapy. Recent advances in the AMS technology at LLNL have allowed for greater sensitivity enabling the use of lower radioisotope and chemical doses, which are imperative for clinical testing. The ability to perform in-human studies has allowed AMS technology to become a valuable tool for the biomedical sciences.
Saturday, February 10 at 9:30 am and 11:15 am